Abstract
BackgroundGenetic polymorphism of human 8-oxoguanine glycosylase 1 (hOGG1) Ser326Cys (rs1052133) has been implicated to alter the risk of prostate cancer, but the results are controversial.MethodsTwo investigators independently searched the Medline, and Cochrane Library up to June 7, 2011. Summary odds ratios (OR) and 95% confidence interval (CI) for Ser326Cys polymorphism and prostate cancer were calculated. Statistical analysis was performed with the software program Review Manage, version 5.0 and Stata 10.0.ResultsA total of 8 independent studies, including 2584 cases and 3234 controls, were identified. Our analysis suggested that Ser326Cys was not associated with prostate cancer risk in overall population. In the subgroup analysis, we detected the significant association between Ser326Cys polymorphism and decreased prostate risk in mixed population under additive model (OR = 0.67, 95% CI = 0.50-0.90, P = 0.007), recessive model (OR = 0.68, 95% CI = 0.51-0.91, P = 0.008), and Cys allele versus Ser allele (OR = 0.88, 95% CI = 0.78-0.98, P = 0.02). Subanalysis on Caucasian subjects demonstrated that Ser326Cys was not associated with prostate cancer risk.ConclusionThis meta-analysis showed the evidence that hOGG1 Ser326Cys polymorphism was associated with a decreased risk of prostate cancer development in mixed populations.
Highlights
Genetic polymorphism of human 8-oxoguanine glycosylase 1 Ser326Cys has been implicated to alter the risk of prostate cancer, but the results are controversial
DNA repair pathways play a critical role in maintaining the genomic integrity in general and specialized functions of cells as well as in the prevention of carcinogenesis, and variations in these genes may lead to higher susceptibility to Prostate cancer (PCa)
Inclusion and exclusion criteria The following inclusion criteria were used to select literatures for the meta-analysis: (1) Only the case-control studies were considered; (2) The paper should clearly describe PCa diagnoses and the sources of cases and controls; (3) The authors must offer the size of the sample, odds ratios (OR) and their 95% confidence interval (CI) or the information that can help infer the results in the papers
Summary
Genetic polymorphism of human 8-oxoguanine glycosylase 1 (hOGG1) Ser326Cys (rs1052133) has been implicated to alter the risk of prostate cancer, but the results are controversial. Not all of those who have been exposed to the risk factors will develop PCa, suggesting the inter-individual differences in susceptibility. One study showed that the hOGG1 326Ser enzyme have higher activity than the 326Cys variant enzyme [5]. Another study data suggested that both 326Ser and 326Cys variant enzymes are functional and do not exhibit significant differences in repair activities [6]. Several eligible case-control studies were performed to identify the association of Ser326Cys polymorphism with PCa risk [8,9,10,11,12,13,14,15].
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