Abstract
BackgroundGenetic polymorphism of human 8-oxoguanine glycosylase 1 (hOGG1) Ser326Cys (rs1052133) has been implicated in the risk of Esophageal Squamous Cell Carcinoma (ESCC). However, the published findings are inconsistent. We therefore performed a meta-analysis to derive a more precise estimation of the association between the hOGG1 Ser326Cys polymorphism and ESCC risk.Methodology/Principal FindingsA comprehensive search was conducted to identify eligible studies of hOGG1 Ser326Cys polymorphism and the risk of the ESCC. Three English and two Chinese databases were used, and ten published case-control studies, including 1987 cases and 2926 controls were identified. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association in the dominant and recessive model. Pearson correlation coefficient (PCC) and standard error (SE) were used to assess the number of Cys allele and ESCC risk in the additive model. Overall, significant associations between the hOGG1 Ser326Cys polymorphism and ESCC risk were found in the recessive model: OR = 1.37 (95% CI: 1.06–1.76, p = 0.02). We also observed significant associations in the Caucasian, Chinese language, population based control and tissue subgroups. In the additive model, positive correlation was found between the number of Cys allele and the risk of ESCC in overall studies (PCC = 0.109, SE = 0.046, p = 0.02), Caucasian subgroup and population subgroup. Funnel plot and Egger's test indicate there was no publication bias in this meta-analysis.ConclusionUnder the published data, the hOGG1 Ser326Cys polymorphism is associated with ESCC risk in the recessive and additive model. Compared with the Ser/Ser and Ser/Cys genotype, Cys/Cys genotype might contribute to increased risk of ESCC. And the risk of ESCC is positively correlated with the number of Cys allele. A better case-control matched study should be designed in order to provide a more precise estimation.
Highlights
Esophageal cancer (EC) is the sixth most common cancer worldwide with 5-year survival rate less than 10% and occurs at a relatively high frequency in certain areas of China [1,2]
Under the published data, the human 8-oxoguanine glycosylase 1 (hOGG1) Ser326Cys polymorphism is associated with Esophageal Squamous Cell Carcinoma (ESCC) risk in the recessive and additive model
A better case-control matched study should be designed in order to provide a more precise estimation
Summary
Esophageal cancer (EC) is the sixth most common cancer worldwide with 5-year survival rate less than 10% and occurs at a relatively high frequency in certain areas of China [1,2]. Genetic variations in hOGG1 gene may alter glycosylase activity, increasing the cancer risk [5]. With a Ser to Cys amino acid substitution at codon 326, Ser326Cys can affect the function of hOGG1. This variation maybe associated with risk of cancer. The results of these studies remained inconclusive and inconsistent In this meta-analysis, by searching individual dataset from all eligible case-control studies published to date, we aimed to estimate the role of hOGG1 Ser326Cys polymorphism in the risk of ESCC as well as to quantify the between-study heterogeneity and potential bias. Genetic polymorphism of human 8-oxoguanine glycosylase 1 (hOGG1) Ser326Cys (rs1052133) has been implicated in the risk of Esophageal Squamous Cell Carcinoma (ESCC). We performed a meta-analysis to derive a more precise estimation of the association between the hOGG1 Ser326Cys polymorphism and ESCC risk
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