Abstract
The HIV/AIDS pandemic has been one of the most significant global health crises, with Sub-Saharan Africa bearing the brunt of its impact. Since the virus emerged in the early 1980s, it has profoundly affected the region, leading to widespread health, economic, and social challenges. Despite advancements in treatment and prevention, the epidemic persists, driven by a complex interplay of factors including inadequate healthcare infrastructure, socio-economic disparities, and pervasive stigma and discrimination. This review provides a comprehensive examination of the HIV pandemic in Sub-Saharan Africa, exploring its origins, epidemiology, and multifaceted impacts on health and society. It also discusses the ongoing challenges in the region’s HIV/AIDS response, including barriers to treatment access, socio-economic determinants, and the need for innovative research and development. Furthermore, the review highlights current prevention, treatment, and international collaboration efforts, and outlines future directions for enhancing access to care, addressing socio-economic factors, and advancing research. Ultimately, this review underscores the need for sustained and coordinated efforts to combat the HIV/AIDS epidemic in Sub-Saharan Africa, with a focus on overcoming the persistent barriers that continue to hinder progress. Keywords: HIV/AIDS, Sub-Saharan Africa, health crisis, treatment, prevention, stigma, socio-economic impact
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