Abstract
The histogenesis of carcinomas and sarcomas induced in the salivary glands of rats.
Highlights
The induction period of sarcomas is slightly longer or of the same order as that for carcinomas, but the cumulative percentage incidence shows a biphasic character with a steep slope followed after 140 days and 220 days by a shallow gradient
5. DMBA in acetone induces carcinomas and sarcomas earlier than DMBA in olive oil, but the subsequent rate of cumulative increase in incidence is the same in both groups
Summary
Onie lhundred anid twenty-ninie male and female black-hooded rats 2 to 5 months old were used for the experiments. 0 1 ml. of a saturated solution of 9,10-dimethyl- 1 2-benzanthracene (DMBA) in acetone or of a 10/ solution of the carcinogen in olive oil was injected under ether anaesthesia into the salivary gland complex on one or both sides of the neck, in some experiments after and in others without surgical exposure of the salivary glands. Of a saturated solution of 9,10-dimethyl- 1 2-benzanthracene (DMBA) in acetone or of a 10/ solution of the carcinogen in olive oil was injected under ether anaesthesia into the salivary gland complex on one or both sides of the neck, in some experiments after and in others without surgical exposure of the salivary glands. An attempt was made to deposit the carcinogen into all 3 salivary glands and 0 0.5 ml. Was given in a posterior direction to the parotid gland. Control animals received a similar quantity of acetone and the injection was made in the same manner as described above. In the animals given the carcinogen in olive oil, the salivary gland complex on the other side of the neck was used as control and injected with 0t 1 ml.
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