Abstract
Electrical stimulation of the hippocampus was used to produce retrograde amnesia in mice. Both subthreshold stimulation and suprathreshold stimulation for the production of hippocampal afterdischarge activity resulted in amnesia for an inhibitory avoidance task. The magnitude of amnesia differed, however, with the two types of stimulation. Histological analysis of the electrode placements indicated that the effective amnesia-producing sites were located in the area dentata of the hippocampus. Electrode placements not bilaterally symmetrical in this area failed to produce amnesia. The role of bilateral symmetry in brain malfunction induced by various experimental treatments is discussed.
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