Abstract
The Hen's Egg Test (HET) is well known as a basic test for embryotoxicity and for special aspects of systemic toxicity and immunopathology. The HET embryotoxicity test has been extended and standardized as the HET-chorioallantoic membrane (CAM) test for membrane irritation. The CAM of fertile White Leghorn eggs incubated for 10 days is a vital vascular membrane, in which irritant effects can be observed following exposure to liquid or solid test materials. The HET-CAM effects are scored and classified to give risk assessments analogous to those of the Draize rabbit-eye test. There is good correlation between classifications based on HET-CAM observations (including electron microscopy) and reported data from Draize tests.
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