Abstract
This aim of this study was to evaluate the hepatotoxic effects associated with pollution caused by spent lubricating oil, a major pollutant in Nigeria on terrestrial organisms. The hepatotoxic effects of three concentrations (10%, 50% and 100%) representing low, medium and high concentration of the water-soluble fraction (WSF) of spent lubricating oil in wistar albino rats was investigated. The range-finding test of WSF of spent lubricating oil was determined to be higher than 100% concentration after 48 hours. Serum L-alanine aminotransferase (L-ALT), L-aspartate amino transferase (L-AST), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) increased significantly (p≤ 0.05) after the administration of 2mL WSF of spent lubricating oil orally for 28 days. The order of increase was 100% >50% >10%. The WSF of spent lubricating oil was slightly acidic with a pH value of 6.7. Histopathological examination of the liver tissues revealed obliteration of sinusoids, macrovesicular fatty change, disorganized cords and enlargement of hepatocytes. The results suggest that oral administration of varying concentration of WSF of spent lubricating oil may cause an adverse effect on the function of the liver.
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