Abstract
Gestational diabetes mellitus (GDM) is a disease with hyperglycemia, insulin resistance and fetal abnormality development. This study was designed to evaluate the hypoglycemic effect and hepatoprotective properties of olive leaves extract.The experimental mice divided into not diabetic group, the control group (GI), and the diabetic pregnant mice were divided into: the diabetic pregnant group (GII) single intraperitoneal injected by streptozotocine (STZ, 240mg/Kg b.wt.). The pregnant mice were given a daily oral dose of olive leaf extract (OLE) only (100 mg/kg) from day 1 to 18 of gestation group (GIII). The diabetic pregnant mice were given daily oral dose of olive leaf extract from day 1 to day 18 of gestation, group (GIV). The STZ-induced diabetic group(GII) exhibited a significant (p<0.05) hyperglycemia, accompanied with a significant increase in serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), enzyme activitieswhen compared with control group. This result is confirmed with extreme histopathological changes in liver tissues and decreased in glutathione peroxidase (GPx) expression. A significant improvement in glucose level, serum AST and ALT enzyme activities showed in (GIV). Also, OLE succeeded to minimize the severe changes in liver tissues of diabetic pregnant mice and their fetuses. Furthermore, level of (GPx) was returned to near normal level. The findings suggest that OLE have a hepatoprotective effect on pregnant diabetic mice and their fetus.
Highlights
The total number of people with diabetes is projected to rise from 171 million in 2000 to 366 million in 2030
This study was conducted on type II diabetic individuals for about nine months at tertiary care hospitals of Swat, which is attended by patients from various districts of all Malakand division as well as from Kohistan and FATA areas of Gilgit etc
Smoker diabetics were excluded from the study, as smoking aggravates the complications of diabetes
Summary
The total number of people with diabetes is projected to rise from 171 million in 2000 to 366 million in 2030. Diabetes mellitus is a chronic debilitating multi system metabolic disorder It is characterized by increased glucose levels in blood and urine resulting from impaired or dysfunction of pancreatic Beta cells or resistance to insulin. The type II diabetes mellitus is the most common one and usually starts at later stages of life (over the age of 40 years). It is an extreme state of glucose intolerance, associates with elevated plasma levels of glucose both before and after its diagnosis and is associated with an increased risk of cancers of the liver, pancreas, colon, endometrium, kidney and breast (Strickler et al, 2001; Czyzyk, and Szczepanik, 2000)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
