The Hepato and Reno Protective Role of Curcumin against the Alterations in Some Biochemical Parameter and Histological Damage Induced by Monosodium Glutamate in Male Albino Rats

Abstract

The main objective of current research was to investigate toxicity effect of Monosodium glutamate and protective role of Curcumin on some blood biochemical parameters, body weight gain, relative organ weight and histopathological alterations in liver and kidney tissues in male albino rats. Twenty animals of male rats (Rattus norvegicus), their weight ranged from 111 to 165 gm. The animals were divided into four groups: Each animal group contained five rat, first group was control negative (-ve) administrated distilled water, the second group was control positive (+ve) administrated curcumin, third group was administrated by Monosodium glutamate (MSG) at dose 20 mg per one Kg and the forth group was administrated by Monosodium glutamate (MSG) at dose 20mg/Kg of body weight + curcumin at dose 100 mg per one Kg of body weight. All animal groups were administrated orally about 30 days. The study recorded significant p≥0.05 increment in liver and kidney function parameters included [Alanine transaminase (ALT), Aspartate aminotransferase (AST), Urea and creatinine] after oral administration of animals with MSG and MSG + Curcumin as a comparison with control groups. The study recorded significant decrement p≥0.05 in liver and kidney function parameters included ALT, AST, Urea and creatinine) in group was administrated MSG + Curcumin in comparison with group was administrated MSG only. Additionally, current study revealed histopathological changes in liver and kidney tissue in groups were administrated MSG and MSG+ curcumin compared with + curcumin compared with control groups. Furthermore, the study revealed that curcumin had protective effect and result in slight histopathological changes in liver and kidney tissue by reducing the damage and in group was treated by MSG+ curcumin for 30 days compared with MSG treated group.