The healing effect of allantoin on skin wounds induced in goats

Abstract

The aim of the present study was to demonstrate the healing effect of allantoin in skin wounds experimentaly induced in goats. Fifteen healthy 12-18-month-old crossbread females goats were divided into three experimental groups: group treated with a comercial formulation of allantoin 3% associated to zinc oxide 3g (GA); control group treated with saline solution (GC) and group treated with a comercial formulation of 35% lauryl dimethyl benzyl ammonium chloride (GP). The wounds were daily treated for 14 days and evaluated on 2nd, 6th, 10th and 14th days by macroscopic characteristcs observations and histological analysis. It was observed a significant increase of wound contraction from the 2nd to 6th post-operative day on the group treated with allantoin while for the microscopic evaluation the collagen deposition was higer on GA groups compared to GC and GP, as well as the inflammatory process was less intense in the allantoin-treated group. In conclusion, it was observed that the allantoin-treated group had a positive effect on inflammation response, collagen deposition and wound contraction, demonstrating that allantoin may be prescribed as an alternative treatment for skin wounds in goats.