The Handbook of Biomarkers

Abstract

1. Introduction -Definitions -Historical aspects of biomarkers -Classification of biomarkers -Types of biomarkers -The ideal biomarker -Biomarkers and systems biology -Relation of biomarkers to other technologies and healthcare 2. Technologies for Discovery of Biomarkers -Introduction -Detection of biomarkers in tissues and body fluids -Disease biomarkers in breath -Genomic technologies -Epigenomic technologies -Proteomic technologies -Glycomic technologies -Metabolomic technologies -Lipidomics -Fluorescent indicators for biomarkers -Molecular imaging technologies -Nuclear magnetic resonance -Nanobiotechnology -Bioinformatics -Pitfalls in the discovery and development of biomarkers 3. Biomarkers and Molecular Diagnostics -Introduction -Molecular diagnostic technologies -Detection and expression profiling of miRNA 4. Biomarkers for Drug Discovery & Development -Introduction -Biomarker technologies for drug discovery -Biomarkers and drug safety -Applications of biomarkers for drug development 5. Role of Biomarkers in Healthcare -Introduction -Biomarkers of inflammation -Biomarkers of oxidative stress -Biomarkers in metabolic disorders -Biomarkers in immune disorders -Biomarkers of musculoskeletal disorders -Biomarkers of osteoporosis -Biomarkers of infectious diseases -Biomarkers of liver disease -Biomarkers of pancreatitis -Biomarkers of renal disease -Biomarkers of pulmonary diseases -Biomarkers in obstetrics and gynecology -Biomarkers for genetic disorders -Biomarkers of aging -Biomarkers of miscellaneous disorders -Biomarkers and nutrition -Biomarkers of gene-environmental interactions in human disease -Future role of biomarkers in healthcare -Applications of biomarkers beyond healthcare 6. Biomarkers of Cancer -Introduction -Types of cancer biomarkers -Molecular diagnostic techniques for cancer -Technologies for detection of cancer biomarkers -Applications of cancer biomarkers -Role of biomarkers in drug development in oncology -Biomarkers according to location/type of cancer -Role of the NCI in biomarkers of cancer -Future prospects for cancer biomarkers 7. Biomarkers of Disorders of the Nervous System -Introduction -Discovery of biomarkers for neurological disorders -Data mining for biomarkers of neurological disorders -Antibodies as biomarkers in disorders of the nervous system -Biomarkers of neural regeneration -Biomarkers of disruption of blood-brain barrier -Biomarkers of neurotoxicity -Biomarkers of neurodegenerative disorders -Biomarkers of multiple sclerosis -Biomarkers of stroke -Biomarkers of traumatic brain injury -Biomarkers of CNS infections -Biomarkers of epilepsy -Biomarkers of normal pressure hydrocephalus -Biomarkers of retinal disorders -Biomarkers for autism -Biomarkers of sleep disorders -Biomarkers of psychiatric disorders 8. Biomarkers of Cardiovascular Disorders -Introduction -Biomarkers of cardiovascular diseases -Methods for identification of cardiovascular biomarkers -Applications of biomarkers of cardiovascular disease -Role of biomarkers in the management of cardiovascular disease -Fut