Abstract
Halophilic archaea/bacteria adapt to different salt concentration, namely extreme, moderate and low. These type of adaptations may occur as a result of modification of protein structure and other changes in different cell organelles. Thus proteins may play an important role in the adaptation of halophilic archaea/bacteria to saline conditions. The Halophile protein database (HProtDB) is a systematic attempt to document the biochemical and biophysical properties of proteins from halophilic archaea/bacteria which may be involved in adaptation of these organisms to saline conditions. In this database, various physicochemical properties such as molecular weight, theoretical pI, amino acid composition, atomic composition, estimated half-life, instability index, aliphatic index and grand average of hydropathicity (Gravy) have been listed. These physicochemical properties play an important role in identifying the protein structure, bonding pattern and function of the specific proteins. This database is comprehensive, manually curated, non-redundant catalogue of proteins. The database currently contains 59 897 proteins properties extracted from 21 different strains of halophilic archaea/bacteria. The database can be accessed through link.Database URL: http://webapp.cabgrid.res.in/protein/
Highlights
The halophilic archaea/bacteria live in a variety of saline habitats
Proteins may play an important role in the adaptation of halophilic archaea/bacteria to saline conditions
The Halophile protein database (HProtDB) is a systematic attempt to document the biochemical and biophysical properties of proteins from halophilic archaea/bacteria which may be involved in adaptation of these organisms to saline conditions
Summary
The halophilic archaea/bacteria live in a variety of saline habitats. Halophilic microorganisms are traditionally defined as organisms that optimally grow in NaCl concentrations of above 0.2 M. Some of these halophilic microorganisms grow in NaCl concentrations of above 5 M. Halophilic organisms mostly fall in three classes with reference to salinity level optimal for their growth: halotolerant (1–6%), moderate (6–15%) and extreme (15–30%). Aerobic halophilic archaea have been extensively studied with reference to their physiology, ecology, biochemistry and bioinformatics. Proteins can exist in globular or fibrous form depending on their function. A polypeptide is a single linear polymer
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