The haemodynamic value of external carotid artery collateral blood supply in carotid artery disease

Abstract

In the presence of severe obstruction of the internal carotid artery (ICA) blood supply to the ipsilateral hemisphere may be provided by collaterals. Whereas the circle of Willis in many cases makes a substantial contribution to cerebral perfusion, the value of collateral blood supply originating from the external carotid artery (ECA) is not clear. In thirty-five patients undergoing carotid endarterectomy (24 with proven external carotid artery collaterals) intra-arterial blood pressures were measured across the ICA stenosis, prior to endarterectomy. In order to evaluate the haemodynamic value of ECA collaterals, the distal ICA pressure was measured with and without the ECA clamped. In addition, volume blood flow in the common carotid artery was measured with and without the ECA clamped, before and after endarterectomy. No significant change in distal ICA pressure was observed when the ECA was clamped, whether or not external carotid artery collaterals had been demonstrated preoperatively. The greatest reduction in mean distal ICA pressure observed upon ECA clamping was 8 mmHg. However, this only occurred in three of 11 patients with a severe pressure reduction across the stenosis. ICA blood flow increased significantly following endarterectomy whereas ECA flow was reduced. This study indicates that ECA collaterals in most cases do not contribute substantially to cerebral perfusion. Endarterectomy of the ECA, in order to improve cerebral circulation, seems justified only in selected cases, where the distal ICA pressure has been shown to be severely reduced.