Abstract
In modern medicine, the oral cavity has often been viewed as a passive conduit to the upper airways and gastrointestinal tract; however, its connection to the rest of the body has been increasingly explored over the last 40 years. For several diseases, the periodontium and gingiva are at the center of this oral-systemic link. Over 50 systemic conditions have been specifically associated with gingival and periodontal inflammation, including inflammatory bowel diseases (IBD), which have recently been elevated from simple “associations” to elegant, mechanistic investigations. IBD and periodontitis have been reported to impact each other’s progression via a bidirectional relationship whereby chronic oral or intestinal inflammation can impact the other; however, the precise mechanisms for how this occurs remain unclear. Classically, the etiology of gingival inflammation (gingivitis) is oral microbial dysbiosis in the subgingival crevice that can lead to destructive periodontal disease (periodontitis); however, the current understanding of gingival involvement in IBD is that it may represent a separate disease entity from classical gingivitis, arising from mechanisms related to systemic inflammatory activation of niche-resident immune cells. Synthesizing available evidence, we hypothesize that once established, IBD can be driven by microbiomial and inflammatory changes originating specifically from the gingival niche through saliva, thereby worsening IBD outcomes and thus perpetuating a vicious cycle. In this review, we introduce the concept of the “gum–gut axis” as a framework for examining this reciprocal relationship between the periodontium and the gastrointestinal tract. To support and explore this gum–gut axis, we 1) provide a narrative review of historical studies reporting gingival and periodontal manifestations in IBD, 2) describe the current understanding and advances for the gum–gut axis, and 3) underscore the importance of collaborative treatment and research plans between oral and GI practitioners to benefit this patient population.
Highlights
A Bidirectional Influence of Oral and Systemic HealthThe oral cavity serves as the entry point to the gastrointestinal tract and is continuous with the nasal cavity and the skin of the face [1]
We will emphasize the idea of this phenomenon likely being uniquely associated with gingival and periodontal inflammation and we introduce the concept of the “gum–gut axis” for the first time as a framework for examining the reciprocal relationship between the periodontium and the gastrointestinal tract
Over many years of work, it is known that gingivitis and periodontitis are caused by a shift from a healthy to a dysbiotic biofilm in the subgingival crevice or “pocket” [35, 36]
Summary
The oral cavity serves as the entry point to the gastrointestinal tract and is continuous with the nasal cavity and the skin of the face [1] While it certainly functions as a conduit for the movement of food, fluids, and air, this space has been revealed to be a diverse collection of tissues that are harmoniously integrated into the vital functions of communication, defense, feeding, breathing, and early digestion [2,3,4]. The most common oral manifestations of IBD involve the buccal mucosa and the gingiva, both of which can display severe, chronic inflammatory lesions This is not surprising, as the anatomy of the periodontium makes this a susceptible site for frequent dysbiosis and chronic inflammation. To support and explore this emerging gum–gut axis, we 1) provide a narrative review of historical studies reporting gingival and periodontal manifestations in IBD, 2) describe the current understanding and advances for the gum–gut axis, and 3) underscore the importance of collaborative treatment and research plans between oral and GI scientists to benefit this patient population
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