Abstract
γ-Type endorphins mimic neuroleptics in inducing a grasping response in rats. It was studied whether the haloperidol-induced grasping response was altered after blockade of γ-type endorphin activity in the rat brain. To achieve this blockade rats were injected i.c.v. with γ-endorphin antiserum or with a monoclonal anti-idiotype desenkephalin-γ-endorphin antibody, which may bio-inactivate the γ-type endorphins or block the putative receptors for γ-type endorphins, respectively. The results showed that both treatments attenuated the haloperidol-induced grasping response, particularly 3 h after haloperidol treatment. The influence of these antibodies appeared to be specific, since other sera were without effect. Thus there may be an interaction between the endogenous γ-type endorphin activity and the haloperidol-induced grasping response.
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