Abstract
To investigate the significance of endogenous, neuroleptic-like γ-type endorphins and their putative receptors, polyclonal and monoclonal antibodies against γ-type endorphins, which may bio-inactivate the ligands for the receptors, and monoclonal anti-idiotype antibodies, which presumably bind to the receptors, were injected into the nucleus accumbens of the rat brain. The desenkephalin-γ-endorphin-induced antagonism of the hypomotility response elicited by challenge with apomorphine injected into the nucleus accumbens was used as test system. Both the anti-desenkephalin-γ-endorphin antibodies and anti-idiotype antibodies blocked the action of exogenous desenkephalin-γ-endorphin. Thus, the anti-idiotype antibodies may serve as receptor antagonists. Chronic treatment (injection into the nucleus accumbens) with the anti-idiotype antibodies induced sustained hypermotility, decreased habituation and impaired passive avoidance behavior. In such treated animals local treatment with apomorphine did not elicit hypomotility. It is suggested that γ-type endorphins influence the setpoint for feedback regulation in dopaminergic neurons equipped with γ-type endorphin receptor systems.
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