Abstract
The periodic-fever syndromes are a genetically heterogeneous group of inflammatory disorders characterized by recurrent fever, abdominal pain, and polyserositis. The clinically distinct entities of familial Mediterranean fever (FMF; MIM 249100) and hyperimmunoglobulinemia D with periodic fever (MIM 260920) are autosomal recessive and genetically distinct. Two Turkish families with clinical features of FMF do not link to the FMF region on chromosome 16p13.3, suggesting genetic heterogeneity for FMF (Akarsu et al.
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