Abstract
Objective: There are many evidences about relationship between eating behavior and drug addiction. A number of susceptibility loci that point to shared higher order genetic pathways underling addiction were found in genetic studies. This study assumed that a genome-wide association study (GWAS) of food addiction would produce important enrichment in genes and pathways related to addiction. Methods: This study done among 314 women of European ancestry, by using a GWAS of food addiction, which is determined by the modified Yale Food Addiction Scale (mYFAS). Results for enrichment of single nucleotide polymorphisms (SNPs) (n 5 44), genes (n 5 238) and pathways (n 5 11) involved in drug addiction were tested. Results: Two loci met GW-significance (P< 2.5 10 -8) with no obvious roles in eating behavior, they are mapping to 17q21.31 and 11q13.4. GW results were significantly enriched for gene members of the MAPK signaling pathway (P = 0.02). After adjustment for multiple testing, candidate SNP or gene for drug addiction was not linked with food addiction. Conclusions: limited support was delivered for shared genetic underpinnings of drug addiction and food addiction, although the GWAS of mYFAS, need further investigation and follow up.
Highlights
In behavioral and neurobiological investigation evidences of association between addiction and feeding behavior is accumulated [1]
genomewide association studies (GWAS) of food addiction would yield substantial of the seven diagnostic criteria plus two enrichment in addiction-related genes and individual items assessing the existence of pathways
GWAS of modified Yale Food Addiction Scale (mYFAS) Two loci met GW-significance General features of the 9,314 women included in the present analysis are shown in Supporting Information Table S1
Summary
In behavioral and neurobiological investigation evidences of association between addiction and feeding behavior is accumulated [1]. Candidate and more recent GWAS of addictive behaviors have given rise to a set of susceptible loci indicating common genetic pathways of higher order underlying addictive behavior [6,7,8], the opportunity to clarify whether specific genetic influences on drug dependency generalize addictive eating. The NHS was founded in 1976 with 121,700 chometric tool for assessing food addiction in in registered female nurses aged 30 - 55 and residing dividuals based on the Diagnostic and Statistical in 11 US states [12]. The NHS2 cohort was set up Manual for Mental Disorders (DSM)-IV codes in 1989 with 116,609 female nurses aged 25-44 for substance dependence criteria [9]. GWAS of food addiction would yield substantial of the seven diagnostic criteria plus two enrichment in addiction-related genes and individual items assessing the existence of pathways
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