Abstract
After studying careful reconstructions of the optic vesicle of the human embryo, the author concludes that growth is by spurts, or waves of tissue energy, and that atypical colobomata have no relation to the closure of the fetal ocular cleft, but result from loss of this growth energy in the tissue at the site of the coloboma, the adjacent tissue growing forward, and connective tissue, if present, attempting to fill up the defect. The time when this lag in tissue growth occurs in the development of the eye determines whether the gap is shallow or deep, whether it involves the choroid and ciliary body or the iris only. From the Wilmer Ophthalmological Institute and the Carnegie Embryological Institute. Presented before the Association for Research in Ophthalmology, in Cleveland, June 12, 1934.
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