Abstract
This study was undertaken with the aim of discovering whether the histologic findings in sympathetic ophthalmia were compatible with the allergy theory of this disease. The relation of melanin granules to the specific histologic features of the inflammation in the uveal tracts, retina, and skin revealed that allergy to uveal pigment is an adequate explanation of these characteristics. However, allergy to uveal pigment may be present without sympathetic ophthalmia. If the allergy theory is correct some additional factor other than allergy is, therefore, necessary to initiate the disease. A study of the Dalen nodules sometimes found in sympathetic ophthalmia suggests that the additional factor may be a proliferation of the melanophores. The results of some preliminary experiments based on this hypothesis are reported. From the Wilmer Ophthalmological Institute of the Johns Hopkins University and Hospital. Read before the Association for Research in Ophthalmology, in Cleveland, June 12, 1934. This study was undertaken with the aim of discovering whether the histologic findings in sympathetic ophthalmia were compatible with the allergy theory of this disease. The relation of melanin granules to the specific histologic features of the inflammation in the uveal tracts, retina, and skin revealed that allergy to uveal pigment is an adequate explanation of these characteristics. However, allergy to uveal pigment may be present without sympathetic ophthalmia. If the allergy theory is correct some additional factor other than allergy is, therefore, necessary to initiate the disease. A study of the Dalen nodules sometimes found in sympathetic ophthalmia suggests that the additional factor may be a proliferation of the melanophores. The results of some preliminary experiments based on this hypothesis are reported. From the Wilmer Ophthalmological Institute of the Johns Hopkins University and Hospital. Read before the Association for Research in Ophthalmology, in Cleveland, June 12, 1934.
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