Abstract
The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene products. Here, we report the advances of the consortium over the past two years. The new GO-CAM annotation framework was notably improved, and we formalized the model with a computational schema to check and validate the rapidly increasing repository of 2838 GO-CAMs. In addition, we describe the impacts of several collaborations to refine GO and report a 10% increase in the number of GO annotations, a 25% increase in annotated gene products, and over 9,400 new scientific articles annotated. As the project matures, we continue our efforts to review older annotations in light of newer findings, and, to maintain consistency with other ontologies. As a result, 20 000 annotations derived from experimental data were reviewed, corresponding to 2.5% of experimental GO annotations. The website (http://geneontology.org) was redesigned for quick access to documentation, downloads and tools. To maintain an accurate resource and support traceability and reproducibility, we have made available a historical archive covering the past 15 years of GO data with a consistent format and file structure for both the ontology and annotations.
Highlights
The Gene Ontology (GO) resource is the world’s most comprehensive source of information about the function of genes and gene products
Regardless, a gene function annotated in GO is always supported by specific evidence describing both the source (e.g. PMID of the article) and the type of the evidence from a subset of Evidence and Conclusion Ontology (ECO) [1]
We focus on our progress on the curation and public release of GOCAM models, the continuous collaborative work to refine the GO ontology, the review and improvement of the quality of our annotations, and the expansion of the usability of GO through a redesigned website, documentation, data access, visualization widget and 15 years of historical archives of the GO knowledgebase
Summary
The Gene Ontology (GO) resource is the world’s most comprehensive source of information about the function of genes and gene products (proteins and non-coding RNAs).
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