The Gender Toxicity of Select Organotin Compounds

Abstract

The work reported here indicates that male Long Evans rats have a greater sensitivity to organotin compound (OTC) than female rats over the 8-day toxic period used in this study, but little discernible difference was observed during the first 72 h following a single oral dose of an organotin compound. No distinct gender difference in the toxicity of organotin compounds was observed for tri- n-butyltin chloride, Di- n-butyltin dichloride, and di- n-octyltin dilaurate during the first 3 days subsequent to administering a dose equal to 75% of the LD 50 for the compounds. Both sexes of the animals were severely affected. After 3 days exposure. the normal acute toxicity observation time for OTC, the females rapidly recover, whereas males continue to languish as evident from the reduced food and water intake, weight loss, continued male deaths, and severe organ damage upon necropsy.