Abstract
Astroblastoma is an uncommon, controversial neoplasm of the Central Nervous System (CNS) emerging from the glia. “Astroblastoma” as a terminology was initially coined in 1924 for a tumefaction characteristically emerging as a unique astrocytic glioma comprised of tumour cells configuring perivascular pseudo-rosettes and appearing immune reactive to Glial Fibrillary Acidic Protein (GFAP). Bucy and Bailey in 1930 delineated diverse macroscopic and microscopic features of the neoplasm with description of individual astroblasts as unipolar cells with broad “feet” amalgamating adjacent to vascular articulations. Subsequently in 1933, Cox categorized astroblastoma as a neoplasm transitioning between astrocytoma and glioblastoma multiforme.
Highlights
Alpha-lipoic acid (ALA) known as lipoate or thioctic acid is abundantly found in brewer's yeast, wheat germ, and red meat [1]
After incubation of both mitochondria in ascorbate (0.4mM)-Fe++ (2.15μM) system (120min at 37°C), non-enzymatic peroxidation, it was observed that the total cpm/mg protein originated from light emission: chemiluminescence was lower in liver and kidney mitochondria obtained from alpha-lipoic acid (ALA) group than in the control group
Incubation of rat liver mitochondria in the presence of ascorbate-Fe++ resulted in membrane peroxidation as evidenced by light emission
Summary
Alpha-lipoic acid (ALA) known as lipoate or thioctic acid is abundantly found in brewer's yeast, wheat germ, and red meat [1]. It remains linked by covalent bonds to the lysine residues of the proteins (lipoyllysine) [2] It is an eightcarbon fatty acid in which sulfur atoms replace the hydrogen atoms of carbons 6 and 8 of the acyl chain (the resulting disulphide oxidation gives ALA) [3] After oral intake, it is absorbed in the small intestine, incorporated into the circulatory tract and effectively crosses the blood-brain barrier [1]. ALA and its reduced form DHLA (dihydrolipoic acid), act as potent free radical neutralizers and metal chelate-forming agents [6,7], but can recycle other antioxidants such as glutathione, Coenzyme Q10 and vitamins
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