Abstract
DNA double-strand breaks (DSBs) is one of the most serious DNA damage, which was recently paid extensive attention to. DNA mismatch repair (MMR) system, widely existing in organisms, is one of the post-replication repair modes that can maintain the stability of genome through correcting base-base mispairs or small insertions/deletions of nucleotides produced in the process of DNA replication and recombination. MMR plays an important role in the process of DSBs repair and MMR proteins can participate in DSBs repair by interacting with the factors of homologous recombination and nonhomologous end joining (NHEJ). This review focuses on the roles of several key MMR proteins in DSBs repair pathways. Key words: MMR; DSBs; Cancer
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