Abstract
Pig livers were cooled in situ by portal vein infusion with Tis‐u‐sol, and were then excised, rewarmed, and perfused in an isolated circuit with diluted autologous blood. The temperature of the cooling fluid was 10°C in one group and 17° C in the other. Bile flow and brom‐sulphllialein excretion in the bile were measured over a 90‐minute period of perfusion at 38° C. The total bile flow and bromsulphthalein excretion were not significantly different in the two groups. However, during the first 30 minutes of perfusion there was a significantly lower bile flow and bromsulphthalein excretion in the bile in the livers cooled to 10° C. The results demonstrated a significant delay in the return of excretory function, and this may be relevant in the choice of methods for preparation of livers for clinical liver perfusion or transplantation.
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