Liver function after cooling with two types of electrolyte solution.

Abstract

Pig livers were cooled in situ by portal vein infusion with cold electrolyte solutions, and then excised and perfused in an isolated circuit with diluted autologous blood. Bile flow and bromsulphthalein excretion in bile were then measured over a 90‐minute period. In one group of experiments the livers were coaled with Hartmann's/dextrose solution, and in the second group the solution was “Tis‐u‐sol” buffered with tromethamine (“Tham”). The livers cooled with “Tis‐u‐sol” had significantly greater bile flows, and excreted significantly more bromsulphthalein, than those cooled with Hartmann's/dextrose.