Abstract
The UDP-Glucuronesyl Transferase (UGT) 2B7*2 802C>T is the most common functional genetic variant on UGT2B7 gene with reported influence on drug response. Objective: To determine the frequency of UGT2B7*2 (802C>T) genetic variant among Jordanian population. Methods: The DNA samples from 90 healthy Jordanian volunteers were analyzed by polymerase chain reaction followed by restriction fragment length polymorphism assays (PCR-RFLP) to determine the UGT2B7*2 allele. Results: The frequency (95% confidence interval) of UGT2B7*2 802C allele was 0.59 (0.52 to 0.66) and for UGT2B7*2 802T was 0.41 (0.34 to 0.48), which was similar to the Caucasian but different than African ethnic populations. The UGT2B7 genotype frequency among Jordanians was 0.31 (0.22 to 0.4) for wild, 0.57(0.47 to 0.67) for heterozygote and 0.12 (0.06 to 0.18) for homozygote UGT2B7*2 genotype. Conclusion: This study reported for the first time the UGT2B7*2 frequency and genotype profile among Jordanians. The findings of this study will increase our understanding in explaining the inter-individual variation in drug response among Jordanian population.
Highlights
UDP-Glucuronosyltransferase 2B7 (UGT2B7) is phase II drug metabolizing enzyme
In comparison with the major ethnic groups, the frequency of UGT2B7 802 C>T among Jordanians was similar to Caucasian (0.52) but significantly higher (z test, p-value
The UGT2B7802C>T genotype frequency was within Hardy-Weinberg (χ2 test, p value >0.05), which indicates that there is no genetic shift in the frequency of UGT2B7802C>T genotype in Jordanians
Summary
UDP-Glucuronosyltransferase 2B7 (UGT2B7) is phase II drug metabolizing enzyme It has a major role in the glucuronidation of endogenous compounds such as estrogen, aldosterone, bile acids, retinoid and fatty acids [1]. This UGT isoform metabolizes around 10% of the total prescribed drugs. It metabolizes opioids, the Nonsteroidal Anti-Inflammatory Drug (NSAIDs), the antiviral zidovudine and the anticonvulsant valproic acid [1,2,3]. It is reported that glucuroronitaed morphine is 100 time more effective than the morphine itself [4,5]
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