Abstract
Objectives Adult onset-Still’s disease (AOSD) and gout are considered as auto-inflammatory disorders. Both diseases run recurrent episodic course and respond to anti-IL 1 treatment. Additionally, increased frequency of MEFV variations in other inflammatory diseases other than FMF such as Behcet’s disease, ulcerative colitis and rheumatoid arthritis and raises the possibility that MEFV gene may play a general role in the inflammatory pathway. Therefore in this study, we explored the MEFV exon 2 and 10 variations in a group of AOSD and gout patients and compared the frequencies between disease groups and healthy controls.
Highlights
Adult onset-Still’s disease (AOSD) and gout are considered as auto-inflammatory disorders
Increased frequency of MEFV variations in other inflammatory diseases other than FMF such as Behçet’s disease, ulcerative colitis and rheumatoid arthritis and raises the possibility that MEFV gene may play a general role in the inflammatory pathway
Published: 28 September 2015 doi:10.1186/1546-0096-13-S1-P15 Cite this article as: Ugurlu et al.: The frequency of MEFV gene variations in Adult-onset Still’s disease and Gout
Summary
Adult onset-Still’s disease (AOSD) and gout are considered as auto-inflammatory disorders. Both diseases run recurrent episodic course and respond to anti-IL 1 treatment. Increased frequency of MEFV variations in other inflammatory diseases other than FMF such as Behçet’s disease, ulcerative colitis and rheumatoid arthritis and raises the possibility that MEFV gene may play a general role in the inflammatory pathway. In this study, we explored the MEFV exon 2 and 10 variations in a group of AOSD and gout patients and compared the frequencies between disease groups and healthy controls
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