Abstract
This study included 100 patients diagnosed with liver cirrhosis who presented at Atatürk University Faculty of Medicine Gastroenterology clinic and polyclinic. The etiology of liver cirrhosis and the incidence of its complications have been investigated. The etiological classification of liver cirrhosis in our patients was as follows: 47 hepatitis B virus hepatitis, 11 hepatitis C virus hepatitis, 5 HBV+HDV hepatitis, 4 Budd Chiari syndrome, 2 chronic alcohol abuse, 2 ischemic heart disease, 1 autoimmune hepatitis, 1 sclerosing cholangitis, 1 hydatid cyst. In 26 patients we could not find any etiological condition. These patients were called cryptogenic cirrhosis patients.When we examined the complications of liver cirrhosis, it appeared that there were ascites in 83 patient. In 56 patients, esophageal variceal bleeding occurred. There was spontaneous bacterial peritonitis in 42 patients. Hepatorenal syndrome occurred in 26 patients. Finally, in 3 patients we detected hepatorenal syndrome. The most common causes in the etiology of liver cirrhosis are viral, especially HBV. Many of the patients were in decompensated phase when diagnosed. We found that there was a close relation between the frequency of complications and mortality in liver cirrhosis.
Highlights
Hepatic cirrhosis is a progressive disease caused by extensive deterioration of hepatic morphological structures via hepatocellular necrosis, increased connective tissue, hepatic regeneration, nodular formation, and fibrotic tissue [1, 2]
The etiology and incidence of disease-related complications in patients diagnosed with hepatic cirrhosis, who presented at the Gastroenterology Clinic and Outpatient Clinic at the Medical School of Ataturk University, were investigated in the current study
Diseases which caused hepatic cirrhosis were HBV in 47 (47%), HCV in 11 (11%), HBV+HDV in 5 (5%), Budd Chiari syndrome in 4 (4%), chronic alcohol use in 2 (2%), ischemic cardiac disease in 2 (2%), autoimmune hepatitis in 1 (1%) 9, sclerosing cholangitis in 1 (1%), and hydatid cyst disease in 1 (1%) patient
Summary
Hepatic cirrhosis is a progressive disease caused by extensive deterioration of hepatic morphological structures via hepatocellular necrosis, increased connective tissue, hepatic regeneration, nodular formation, and fibrotic tissue [1, 2]. HBV is the main cause of cirrhosis in developing countries. Viral hepatitis is the etiologic factor in 60% of hepatic cirrhosis cases in Turkey [3, 4]. The main complications of hepatic cirrhosis are hepatocellular carcinoma as the result of a lack of hepatocellular functionality, jaundice, coagulation defects and hypoalbuminemia. The etiology and incidence of disease-related complications in patients diagnosed with hepatic cirrhosis, who presented at the Gastroenterology Clinic and Outpatient Clinic at the Medical School of Ataturk University, were investigated in the current study
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