Abstract
Our previous work demonstrating the action of small amounts of hemolytic substances as castor oil soap and saponin in decreasing and increasing the fragility of red blood cells would seem to have some bearing upon the fragility test as used in medical diagnosis. The preliminary work to determine the role of adsorption hemolysis in clinical conditions is here reported.Bile from various animals has been used as a hemolytic agent for various animal erythrocytes and we have found its action to be very variable in different samples. The surface tension of bile solutions has also been studied and its surface tension, reducing property is likewise very variable.There is a very marked relation between the time of hemolysis and relative surface tension. Some samples of bile have shown a decrease in surface tension upon dilution with salt solution and coordinate with this has occurred a decrease in the time of hemolysis. When erythrocytes are treated with non-hemolytic concentrations of bile, the fragility of the c...
Published Version
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