Abstract
The dose-related yields of the three kinds of pyrimidine dimer induced in DNA by ultraviolet light of 254 nm have been measured in three species of bacteria ( Escherichia coli, Micrococcus luteus and Bacillus subtilis) and two species of fungi ( Saccharomyces cerevisiae and Ustilago maydis). The yield in each organism is related to its base composition. When allowance is made for differing nearest-neighbour frequencies, it is found that CC , CT and TT dimers form in the approximate ratios of 1:1:2 at doses of ultraviolet light below 2000 ergs/mm 2. Dimers are formed in native DNA at twice the rate they are formed in cells.
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Schedule a callMore From: Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis
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