Abstract
Clinical background The biphasic transmittance waveform (BTW) refers to a time-dependent decrease in light transmittance that often occurs prior to clotting when performing the activated partial thromboplastin time (aPTT) assay with plasmas of critically ill patients on the MDA® coagulation analyzer [1]. Early observations showed an association of the BTW with disseminated intravascular coagulation (DIC) and clinical outcome. (See Table 1) The magnitude of the BTW was assessed against in-patient mortality. A total of 346 patients were found to have a BTW on admission to the ITU with a mortality rate of 44%, as compared with 26% for those with normal waveforms. A stepwise increase in the likelihood of mortality was directly correlated with the from 3rd International Conference on cGMP Generators, Effectors and Therapeutic Implications Dresden, Germany. 15–17 June 2007
Highlights
Michael Nesheim*1, John Samis2, John Walker1, Timothy Fischer3,5, Liliana Tejidor3, Greg Jones3, Wim Houdijk3, Alan Giles3, Lev Becker1, Marlys Koschinsky1, Richard Wenstone4, Colin Downey4 and
3rd International Conference on cGMP Generators, Effectors and Therapeutic Implications Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here.
With disseminated intravascular coagulation (DIC) and clinical outcome. (See Table 1) The magnitude of the BTW was assessed against in-patient mortality
Summary
Michael Nesheim*1, John Samis, John Walker, Timothy Fischer, Liliana Tejidor, Greg Jones, Wim Houdijk, Alan Giles, Lev Becker, Marlys Koschinsky, Richard Wenstone, Colin Downey and. Address: 1Department of Biochemistry, Queen's University, Kingston, Ontario, Canada, K7L 3N6, 2Department of Pathology, Queen's University, Kingston, Ontario, Canada, K7L 3N6, 3Organon Teknika Corporation, Durham, NC 27712, USA, 4Department of Haematology, Royal Liverpool University Hospital, Liverpool, L7 8XP, UK and 5Ventana Medical Systems, Tucson, Arizona, USA. Published: 25 July 2007 BMC Pharmacology 2007, 7(Suppl 1):P42 doi:10.1186/1471-2210-7-S1-P42. 3rd International Conference on cGMP Generators, Effectors and Therapeutic Implications Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here.
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