Abstract
Several steps in the formation of new blood vessels have been elucidated. Among these steps are breakdown of surrounding extracellular matrix, migration of vascular endothelial cell to form an advancing new blood vessel sprout, and endothelial cells proliferation at the base of the sprout. Two other important events in the process of new blood vessel formation have yet to receive much attention. These steps are formation of the new blood vessel lumen and maintenance of the new blood vessels. The importance of the maintenance of new blood vessels becomes apparent when one realizes that new blood vessels regress rapidly once the stimulating factor or factors are removed. We will therefore present two sets of studies. The first set of studies relates to the in vitro formation of capillary like structures by vascular-endothelial cells. The mechanism of lumen formation in this model is described. It is not clear whether this mechanism of lumen formation occurs in vivo. The second set of studies elucidates some of the factors that may play a role in the maintenance of new blood vessels and their subsequent regression upon removal of the angiogenic stimulators.
Published Version
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