Abstract
BackgroundFlavonoids are reported to modulate the composition of gut microbiota, which play an important role in preventing obesity and associated metabolic diseases. In this study, we investigated the effect of Total Flavonoids of Quzhou Fructus Aurantii Extract (TFQ) on gut microbial community in mice fed with a high-fat diet (HFD).MethodsC57BL/6J mice were fed with either a chow diet or HFD with or without oral gavage of TFQ (300 mg/kg/day) for 12 weeks.ResultsOur data indicate TFQ significantly reduced obesity, inflammatio,n and liver steatosis. TFQ elevates the expression of tight junction proteins and reduces metabolic endotoxemia. In addition, TFQ treatment reverses HFD-induced gut dysbiosis, as indicated by the reduction of Firmicutes to Bacteroidetes ratio, the increase of genera Akkermansia and Alistipes, and the decrease of genera Dubosiella, Faecalibaculum, and Lactobacillus.ConclusionThese findings support a prebiotic role of TFQ as a dietary supplement for the intervention of gut dysbiosis and obesity-related metabolic disorders.
Highlights
Obesity is a growing public health concern which strongly influences the quality of human life[1]
We investigated the influence of the Quzhou Fructus Aurantii extract, 60–70% of which consisting of flavonoids, on gut microbiota in a high-fat diet-fed mice model
Epididymal white adipose tissue (WAT) weight (n = 12). c Left, the representative images of H&E staining in liver from each group
Summary
Obesity is a growing public health concern which strongly influences the quality of human life[1]. The clinical and experimental studies have provided compelling evidence that flavonoids intake aids in preventing obesity and type. Flavonoids can be transformed by gut microbes into metabolites with increased or decreased biological activities[14]. Flavonoids such as hesperidin[15], quercetin[16], and Cyclocarya paliurus flavonoid[17], have been reported to modulate the composition of gut microbiota by increasing probiotics and reducing pathogens, which play an important role in preventing obesity and associated metabolic diseases. Flavonoids are reported to modulate the composition of gut microbiota, which play an important role in preventing obesity and associated metabolic diseases. We investigated the effect of Total Flavonoids of Quzhou Fructus Aurantii Extract (TFQ) on gut microbial community in mice fed with a high-fat diet (HFD)
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