Abstract
J147 was synthesized from 2,4-dimethylphenylhydrazine hydrochloride and 3-methoxybenzaldehyde in 2 steps with 71% overall yield. The precursor desmethyl-J147 was synthesized from 3-hydroxybenzaldehyde and 2,4-dimethylphenylhydrazine hydrochloride in 4 steps with 63% overall yield. [11C]J147 was prepared from desmethyl-J147 with [11C]CH3OTf through O-[11C]methylation and isolated by HPLC combined with solid-phase extraction (SPE) in 35–50% radiochemical yield based on [11C]CO2 and decay corrected to end of bombardment (EOB), with 370–740GBq/μmol specific activity at EOB.
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