The first isolate of Klebsiella pneumoniae Carbapenemase (KPC)–producing Klebsiella pneumoniae at a regional hospital

Abstract

Results: Repigel treatment showed no recovery of P. aeruginosa biofilm material (>5 Log reduction vs. untreated controls) at both the commercial concentration and 1:10 dilution at both time-points. Topical preparations containing mupirocin 2% and fusidic acid 2% showed no difference vs. controls at 1:10 dilution. Four hours of treatment did not significantly reduce the biofilm load, but a >1 Log reduction in P. aeruginosa biofilm material was demonstrated after 24 hours. Treatment of mixed C. albicans/MRSA biofilms with Repigel TM resulted in a 5 Log reduction in biofilm material at both time-points. The 1:10 dilution of Repigel TM produced a >1 Log reduction in mixed biofilm material at both time-points, similar to findings with the other topical preparations. Conclusions: Repigel TM at commercial concentration and 1:10 dilution prevented the recovery of viable P. aeruginosa biofilm material and reduced the recovery of viable organisms from multispecies biofilms of C. albicans and MRSA. The efficacy of Repigel TM in this in vitro model supports its potential antiseptic effectiveness against multiple bacterial strains in exuding chronic wounds. Funded: Mundipharma