Abstract
Objective: To evaluate the relationship of the blood fibrinogen (FIB) degradation product (FDP) level and FDP/FIB ratio with seizure in young children with fever.Methods: A total of 35 children with simple febrile seizures and 80 children with fever but no seizure were selected. First, the differences in white blood cell (WBC), platelets (PLT), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), FIB, FDP, FDP/FIB ratio, and C-reactive protein (CRP) between 35 children with simple febrile seizures and 40 randomly selected children with fever but no seizure were retrospectively analyzed. Then, an ROC curve was used to determine the diagnostic utility of the FDP level, FDP/FIB ratio, and FDP+FDP/FIB ratio, and the best diagnostic cutoff points were selected. Finally, the diagnostic specificities of the three diagnostic indicators were verified by comparison with the results of all 80 children with fever but no seizure.Results: The FDP level and FDP/FIB ratio were significantly different between the two groups (P < 0.0001) and there was a positive correlation between the FDP and FIB levels. Both the FDP level and FDP/FIB ratio had good diagnostic value. An FDP ≥ 2.0 mg/L and FDP/FIB ratio ≥ 0.5 had good diagnostic specificities. Combined application of an FDP ≥ 2.0 mg/L and FDP/FIB ratio ≥ 0.5 improved the diagnostic power.Conclusions: The blood FDP level and FDP/FIB ratio may be related to seizures after fever, and an FDP ≥ 2.0 mg/L + FDP/FIB ratio ≥ 0.5 has good diagnostic specificity.
Highlights
Fever is a common sign of pediatric emergency in children younger than 5 years of age, mostly due to infections
The seizure type in simple febrile seizures (SFS) group was tonic-clonic with a duration
FIB enters the nervous system through blood–brain barrier leakage [7], and a high level of FIB in tissues is closely related to Alzheimer disease severity [18], indicating that enhanced permeability of the blood–brain barrier plays a key role in the occurrence of multiple sclerosis, Alzheimer disease, and other neurological diseases [19, 20]
Summary
Fever is a common sign of pediatric emergency in children younger than 5 years of age, mostly due to infections. Whether fever can cause seizures, and which children with fever are at risk of seizures, are matters of great concern to pediatricians and parents. Febrile seizures (FS), simple febrile seizures (SFS), is the most common cause of seizure [1, 2]. FS is a type of seizure accompanied by fever that is seen in children aged 6 months to 5 years with no evidence of infection in the central nervous system or other identifiable causes of seizure [3]. SFS is one subtype of FS with seizures that last for
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