Abstract
BackgroundA formulation of black cumin (Nigella sativa L.), licorice (Glycyrrhiza glabra L.), anise (Pimpinella anisum L.) and tea (Camellia sinensis (L.) Kuntze) (denoted BLAB tea) is traditionally used to relief allergy reaction including allergic rhinitis. However, little is known about its underlining mechanism of anti-allergic effects.MethodsTo investigate the anti-allergenic mechanism of BLAB tea, we treated ovalbumin (OVA)-induced allergic rhinitis (AR) model of mice with BLAB tea, and elucidated its possible mechanism of action. Mice in the control group were treated with phosphate-buffered saline only. Subsequently, the infiltration of different inflammatory cells was measured. In addition, histopathological changes in the nasal mucosa, and the levels of allergen-specific cytokines and OVA-specific immunoglobulins were measured.ResultsThe aqueous extract of BLAB significantly alleviated the nasal symptoms and reduced the accumulation of inflammatory cells in the nasal mucosa and nasal lavage fluid of AR model of mice.ConclusionThe aqueous extract of BLAB induced the production of Th1 and Treg cytokines and inhibited the release of Th2 cytokines and histamine in nasal mucosa and serum of mice while decreasing the serum levels of OVA-specific IgE, IgG1, and IgG2a. These results suggest the potential of the aqueous extract of BLAB as a treatment option for allergic diseases.
Highlights
A formulation of black cumin (Nigella sativa L.), licorice (Glycyrrhiza glabra L.), anise (Pimpinella anisum L.) and tea (Camellia sinensis (L.) Kuntze) is traditionally used to relief allergy reaction including allergic rhinitis
The aqueous extract of BLAB significantly alleviated the nasal symptoms of OVA‐induced Allergic rhinitis (AR) mice Sneezing and rubbing are commonly used to evaluate the effects of drugs on AR mice
Results from the Diff-Quik staining showed that the number of eosinophils, neutrophils, and lymphocytes increased significantly in the OVA group, while the numbers decreased in nasal lavage fluid (NALF) of BLAB 200 and BLAB 400 group (Fig. 2B)
Summary
A formulation of black cumin (Nigella sativa L.), licorice (Glycyrrhiza glabra L.), anise (Pimpinella anisum L.) and tea (Camellia sinensis (L.) Kuntze) (denoted BLAB tea) is traditionally used to relief allergy reaction including allergic rhinitis. Allergic rhinitis (AR), known as hay fever, is a chronic respiratory disease affecting 10–30% of the global population [1]. It is characterized by symptoms such as sneezing, nasal congestion, runny nose, and. Liao et al Allergy Asthma Clin Immunol (2021) 17:87 with the imbalance of Th1/Th2, resulting in the activation of Th2 cells and suppression of Th1 cells [5]. Regulatory T (Treg) cells, which are known to inhibit the proliferation and activation of conventional effector. It can be hypothesized that regulation of the Th1/Th2/Treg immune balance may be an effective treatment strategy for AR and other allergic diseases [7]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
