Abstract
The T-bet m RNA level was lower in the PV and PCV group than Der f group (p< 0.05). The IL-13, GATA-3 mRNA level and serum Der f-specific IgE and eosinophil were lower in the PV and PCV group than Der f group (p< 0.05). Foxp3 mRNA expression in the PV and PCV group was elevated compared to the Der f group (p < 0.05). In flow cytometry, the PV group (p < 0.05) and the PCV group (p < 0.05) had higher percentages of CD4+ CD25+Foxp3+ T cells than the Der f group. In the PV group, the percentage of these cells was higher than that in the PCV group. (p=0.00). Conclusions These results suggest that the pneumococcal polysaccharide vaccines will suppress the allergen-specific Th2 response and enhanced the induction of regulatory T cells in a model of allergic rhinitis. And the process to work regulatory T cell can be different between the PV and PCV group.
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