Abstract
The purpose of this study was to quantify the expressions of XO and MDA in the gingival tissues of the chronic periodontitis associated with HTN. Xanthine oxidase (XO) generates reactive oxygen species. Malondialdehyde (MDA) is one of many low molecular weight end-products of LPO and is the most often measured as an index of peroxidation. Depending on the patients systemic condition and clinical criteria of gingiva, each gingival sample was divided into three groups. Group 1 is clinically healthy gingiva. Group 2 is inflamed gingiva from with chronic periodontitis. Group 3 is inflamed gingiva from with chronic periodontitis associated with HTN. The expression levels of XO increased in order of group 1, group 2 and group 3, and significantly increased in group 3 as compared to group 1. The expression levels of MDA increased in order of group 1, group 2 and group 3. MDA expression was significantly higher in group 2 than in group 1, and the quantitative analysis of MDA level was significantly higher in group 3 than in group 1. In conclusion, this study demonstrated that the expression levels of XO and MDA might be inflammatory and bone resorption marker in periodontal inflammed tissue. It is assumed that hypertension may be associated with the progression of periodontal inflammation and alveolar bone resorption.
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