Abstract
To investigate the expression profile and diagnostic potentials of serum miR-92a, 134, and 375 in acute ischemic stroke (AIS) patients. Serum miRs-92a, 134, and 375 expression profiles were estimated by qRT-PCR for 70 AIS patients, age-matched with 25 control subjects. Their diagnostic potential was estimated by ROC analysis. Down-expression of miR-92a and miR-375 was found (56; 96.5%; -1.86±1.36; and 53; 91.4%; -1.63±1.38, respectively), while miR-134 showed a predominant upregulation (46; 79.3%; 0.853±1.34). The diagnostic accuracy was the highest for miR-92a and miR-375 (area under the curve=0.9183 and 0.898, respectively), with greater specificity for miR-375 (Sp=96%). Serum miR-92a and miR-375 could be promising early detective biomarkers of AIS.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call