Abstract
The amyloid precursor protein (APP) plays an important role in the pathogenesis of Alzheimer's disease. Using a proteomics approach we have shown before, that APP, the APP-binding protein and the APP-p-component are also highly expressed in benign cold thyroid nodules. APP has been identified as a potent stimulator of thyroid cell proliferation. In addition, the thyroid hormone trijodthyronine (T3) influences APP gene splicing, APP processing and secretion. In this study we analyzed (I) APP mRNA splicing, (II) APP protein expression with NH2- and COOH-terminal epitopes and (III) the expression of important APP scaffold proteins in a panel of benign and malignant thyroid pathologies to further elucidate the role of APP in thyroid tumorigenesis.
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