Abstract
Objective:Analysis of phosphatidyl inositol 3-kinase catalytic subunit of alpha(PIK3CA) expression in nasopharyngeal carcinoma and prognosis.Method:On normal nasopharyngeal mucosa and tissue adjacent to carcinoma and nasopharyngeal carcinoma tissues serine/threonine protein kinase (pAkt) and the expression of PIK3CA status detection,immunohistochemical method,in-depth analysis is made to the relationship between the development of tumor; The expression of tumour stage,prognosis and IK3CA comprehensive analysis of the relationship between.Result:Tissue adjacent to carcinoma,pAkt in nasopharyngeal carcinoma tissue,the expression of PIK3CA increased significantly(P<0.05). There was a significant correlation between the degree of overexpression of PIK3CA and clinical stage(T stage: r=0.437,P<0.01;N stage: r=0.318,P<0.05; clinical stage:r=0.496,P<0.01).Compared with PIK3CA-negative patients,PIK3CA-positive patients had a worse overall survival(P<0.01).Conclusion:PIK3CA is highly expressed in nasopharyngeal carcinoma,which is significantly associated with worse clinical stage and worse overall survival prognosis.
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Schedule a callMore From: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
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