The expression of COX-2 and Survivin protein in gastric carcinoma and its clinical significance

Abstract

Objective To investigate the expression and clinical significance of COX-2 and Survivin protein in gastric carcinoma.Methods In 76 gastric carcinoma specimen and 13 normal mucosa gastric specimen,the exprssion of COX-2 and Survivin protein were detectede by immunohistochemistry SP.The relationship between expression of COX-2 and Survivin protein and clinical pathological parameter were analyzed,also the relationship between COX-2 and Survivin protein.Results The positive expression rate of COX-2 and Survivin protein was 80.26% and 77.63%,and higher than those in normal gastric tissues (P＜0.01).The positive expression of COX-2 protein was negatively related to gender,age,cellular differentiation,serosa infiltration (P＞0.05),but associated with lymph node and TNM stage (P＜0.05).The positive expression of Survivin protein was not related to gender,age (P＞0.05),but associated with cellular differentiation,serosa infiltration,lymph node metastasis and TNM stage (P＜0.05),The expression of COX-2 protein was positively correlated with Survivin protein (P＜0.01).Conclusion COX-2,Survivin protein play an important role in the genesis and development of gastric carcinoma.The expression of Survivin and COX-2 protein may be the index of prognostic evaluation and determination of biological behavior in gastric carcinoma. Key words: Stomach neoplasms; Epoxide hydrolases; Survivin; Immunohistochemistry