Abstract
Protein phosphatase 2A (PP2A) activity may be differentially regulated by the expression of proteins containing a related amino acid sequence motif such as the casein kinase 2α (CK2α) subunit or SV40 small t antigen (SVt). Expression of CK2α increases PP2A activity whereas SVt decreases its activity. In this work we have tested for the effect of the expression of a third protein containing a similar motif that could be involved in PP2A regulation, the catalytic casein kinase 2α′ subunit. Our results show that despite the structural similarity of this protein with the other CK2 catalytic (α) subunit, the function of the two subunits with respect to the modulation of PP2A activity is quite different: CK2α increases whereas CK2α′ slightly decreases PP2A activity.
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