Abstract
Objective To study the expression change of forkhead box protein M1 (FoxM1) and NIMA-related kinase 2 (Nek2) in kidney cancer tissues and its clinical significance. Methods Twenty-five kidney cancer patients who underwent surgical removal of kidney cancer and adjacent tissues were randomly chosen. The specimens were diagnosed by pathology. The expression changes of FoxM1 and Nek2 were detected by Western blot and immunohistochemical method. Results The expression level of FoxM1 in kidney cancer tissues was significantly higher than that in adjacent tissues (P<0.05), the expression level of Nek2 in kidney cancer tissues was also significantly higher than that in adjacent tissues (P<0.05). The expression of FoxM1 and Nek2 in kidney cancer tissues was positively correlated (r=0.915, P<0.05). Conclusions The expression level of FoxM1 and Nek2 increases significantly in kidney cancer tissues, which may lead to the development and progression of kidney cancer. FoxM1 and Nek2 may be beneficial to the diagnosis and prognosis of kidney cancer. Key words: Kidney Neoplasms; Forkhead Box Protein M1; Protein Kinases
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