Abstract
Objective To examine the expressions of serum growth hormone(ghrelin), leptin(LP), insulin-like growth factor-1(IGF-1)and insulin-like growth factor binding protein-3(IGFBP3)in children with idiopathic short stature(ISS), and their significance. Methods A total of 40 patients with ISS were selected from May. 2012 to Oct. 2014 in Fuyang Maternal and Child Health Hospital, while a total of 40 children in good health were selected as the control group. Serum ghrelin and LP levels were measured by ELISA. Serum IGF-1 and IGFBP3 levels were detected by chemiluminescence immune assay. Results were analyzed statistically. Results The height, weight, BMI, GH, serum LP, IGF-1, and IGFBP3 levels in the observation group were significantly lower than those in the control group, while serum ghrelin expression level was significantly higher than that in the control group(P< 0.05). The correlation analysis showed that ghrelin and LP were negatively correlated(r=-0.611, P<0.01), ghrelin and IGF-1 levels were negatively correlated(r=-0.520, P<0.05), Ghrelin and IGFBP3 were positively correlated(r= 0.586, P<0.01), IGF-1 and IGFBP3 was negatively correlated(r=-0.576, P<0.01), and LP and IGFBP3 were negatively correlated(r=-0.609, P<0.01). Conclusions It shows that ghrelin, LP, IGF-1, and IGFBP3 levels in children with ISS are related to growth hormone secretion status. The interactions between ghrelin and insulin-like growth factor axis regulate growth and development of children. Key words: Idiopathic short stature; Insulin-like growth factor; Insulin-like growth factor binding protein; Ghrelin
Published Version
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