Abstract
Objective To evaluate the expression and significance of Beclin1 and LC3 in tumor budding of oral squamous cell carcinoma. Methods Immunohistochemical and H.E staining were used to detect the Beclin1 and LC3 expression and assess tumor budding in 34 patients with oral squamous cell carcinoma. The association among Beclin1, LC3, tumor budding and patient clinical features were analyzed with Chi-square test. Data were analyzed by Chi square test using SPSS 19.0 statistical software. Results Decreased expression of Beclin1 and LC3 was confirmed in cancer center when compared with adjacent non-cancerous tissue. Similar results were also observed in tumor budding cells when compared with cancer center. The decreased expression of LC3 in tumor budding was associated with cervical lymph node metastasis and clinical stage in patients with oral squamous cell carcinoma (P<0.05) . Conclusion The activity of autophagy was decreased in tumor budding, which was associated with cervical lymph node metastasis in oral squamous cell carcinoma. Key words: Carcinoma, Squamous cell; Autophagy; Beclin1; LC3; Tumor budding; Lymphatic metastasis
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