Abstract
Objective To explore the clinical significance of expression of MKK4 in osteosarcoma,and to discuss the relationship between MKK4 and osteosarcoma occurrence,development and prognosis. Methods The expression of MKK4 protein was determined with immunohistochemical SP method in 30 cases of osteosarcoma. Results The MKK4 was obviously expressed in both nucleus and cytoplasm in osteosarcoma.The expression of MKK4 in the cytoplasm of osteosarcoma was positively correlated with clinical stage(r= 0.72,P= 0.000),the expression of MKK4 in the nucleus of osteosarcoma had no correlation with clinical stage(r= 0.44,P= 0.080).MKK4 expression in the cytoplasm was higher in transfer osteosarcoma than no transfer osteosarcoma(χ2= 9.69,P<0.01),while no obvious difference in the nucleus of osteosarcoma(χ2= 1.00,P= 1.000). Conclusion The MKK4 is highly expressed in the nucleus and cytoplasm of osteosarcoma,suggests that MKK4 may be related with the carcinogenesis development of osteosarcoma.The expression of MKK4 in the cytoplasm of osteosarcoma is related to the malignant,metastasis and prognosis of osteosarcoma,may be used as a potential prognostic indicator of judgment osteosarcoma. Key words: JNK mitogen-activated protein kinases; Osteosarcoma
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