The expression and clinical significance of kinesin superfamily proteins 18A in bladder cancer tissues

Abstract

Objective To investigate the expression level of kinesin superfamily proteins 18A (KIF18A) in bladder cancer tissues and its correlation with clinicopathological features. Methods The clinical data, bladder cancer tissues and adjacent normal tissues samples of 63 patients who underwent radical cystectomy in our hospital from October 2016 to December 2018 were collected. To the normal tissue of the cancer side as a control, to detect the level of KIF18A expression in bladder cancer tissue, according to staining results, bladder cancer patients were divided into KIF18A low expression group and KIF18A high expression group, using the chi-square test or Fisher precision test to compare the clinical and pathological characteristics between the groups, Analysis of the correlation between the degree of expression of KIF18A in bladder cancer tissue and clinical pathological characteristics. Results The high expression rate of KIF18A in bladder cancer tissues was 55.6% (35/63) and the low expression rate was 44.4% (28/63). The high expression rate of KIF18A in normal tissues was 28.6% (18/63) and the low expression rate was 71.4% (45/63). KIF18A expression in bladder cancer was significantly different from that in adjacent normal tissues (χ2=9.412, P 0.05), age (χ2=0.268, P>0.05), the tumor diameter (χ2=0.121, P>0.05), N staging (lymph node involvement staging χ2=4.882, P>0.05), M staging (distant metastasis staging χ2=1.690, P>0.05). T staging (tumor invasion staging χ2=9.264, P<0.05) and pathological grading (χ2=5.119, P<0.05) was significantly related to the high expression rate of KIF18A. Conclusion KIF18A is up-regulated in bladder cancer, and its high expression is positively correlated with T stage and pathological grade. Key words: Bladder cancer; Kinesin superfamily proteins; Kinesin superfamily proteins 18A; Clinicopathologic features